Peripheral sensitization, central sensitization and postoperative pain chronifcation
نویسندگان
چکیده
منابع مشابه
Pain: current aspects on peripheral and central sensitization.
BACKGROUND AND OBJECTIVES Current research has focused on the biochemical and structural plasticity of the nervous system secondary to tissue injury. The mechanisms involved in the transition from acute to chronic pain are complex and involve the interaction of receptor systems and the flow of intracellular ions, second messenger systems, and new synaptic connections. The aim of this article wa...
متن کاملCentral sensitization pain should be included in (central) neuropathic pain.
Dr. Nijs et al (1) provided criteria for the classification of central sensitization (CS) pain. Peripheral neuro-pathic pain and nociceptive pain cause CS in the central nervous system if the 2 kinds of pain persist. Therefore, pure peripheral neuropathic pain and pure nociceptive pain are rare in clinical practice. I believe that CS is one of causes of central neuropathic pain. CS pain may be ...
متن کاملExperimental pain responses support peripheral and central sensitization in patients with unilateral shoulder pain.
OBJECTIVE The aims of this study were to (1) examine the pattern of experimental pain responses in the affected and nonaffected extremities in patients with shoulder pain and (2) explore the intraindividual association between sensitization states derived from experimental pain testing. METHODS Experimental pain responses from 58 patients with shoulder pain (17 women, aged 18 to 52 y) were co...
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Temporomandibular joint disorder is characterized by peripheral and central sensitization of trigeminal nociceptive neurons. Although CGRP is implicated in the development of central sensitization by stimulating glial activation via its receptor, the mechanism by which CGRP promotes and maintains sensitization of trigeminal nociceptive neurons is not well understood. The goal of my study was to...
متن کاملSpinal and supraspinal contributions to central sensitization in peripheral neuropathy.
We will focus on spinal cord dorsal horn lamina I projection neurones, their supraspinal targets and involvement in pain processing. These spinal cord neurons respond to tonic peripheral inputs by wind-up and other intrinsic mechanisms that cause central hyper-excitability, which in turn can further enhance afferent inputs. We describe here another hierarchy of excitation - as inputs arrive in ...
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ژورنال
عنوان ژورنال: Revista Dor
سال: 2017
ISSN: 1806-0013
DOI: 10.5935/1806-0013.20170041